I'm using 24kBit/s 11,025Hz Stereo 3KB/s for my movies/trailers and 18kBit/s 11,025Hz Stereo 3KB/s for my anime/cartoons.
Both are set to high quality and 11025Hz sampling rate in the Ctrl-O Options menu.
Not sure if these settings are for you but I haven't had any complaints from those happy...